ArticleTropical medicine and health2026
Effectiveness of dimeticone oils versus sodium carbonate solution in the treatment of tungiasis in Kenya: a non-inferiority randomised trial.
Article in Tropical medicine and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundTungiasis is a cutaneous parasitic disease caused by the female flea Tunga penetrans. The World Health Organization recommends two-component dimeticone (NYDA
methodsA randomised, observer-blinded, non-inferiority trial was conducted, with the non-inferiority margin set at 10%. A total of 160 eligible children with 941 flea infections were matched and randomised. The number of lesions per child per foot ranged from 1 to 10, with a median of 5 lesions. Each participant received both treatments, with one treatment applied to each foot. Health conditions, including inflammation scores and adverse events, were recorded. Observations were recorded on days 3, 5, 7, 9, and 11 using a digital microscope to determine flea viability.
resultsData from 157 children aged 4-15 years were analysed, comprising a total of 843 lesions. On day 11, the proportion of dead fleas was 88% for NYDA
conclusionsThis study demonstrated that 5% sodium carbonate did not meet the non-inferiority margin compared with NYDA
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