Evidence map›Paper›PMID 41821043›Full record

ArticleJournal of neuroengineering and rehabilitation2026

Noisy galvanic vestibular stimulation improves postural stability under virtual reality perturbation by enhancing vestibular processing and multisensory integration.

Haoyu Xie, Yan Li, Zengming Hao, Liping Zhao, Jung Hung Chien, Chuhuai Wang

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Article in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Haoyu Xie *Department of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yan Li *Department of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zengming HaoDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Liping ZhaoDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Jung Hung ChienDr. Sid E. Williams Center for Chiropractic Research, Life University, Marietta, GA, USA. jung.chien@life.edu.
Chuhuai WangDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. wangchuh@mail.sysu.edu.cn.

Funding

2026 Suzhou Municipal Hospital Ke Jiao Xing Wei Special Fund Szslyyrc202601040Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110185Guangdong-Hong Kong Technology and Innovation Cooperation Funding 2023A0505010014National Key Research and Development Program of China 2022YFC2009700National Natural Science Foundation of China 82172532
6 · The paper itself

Abstract

backgroundNoisy galvanic vestibular stimulation (nGVS) is a non-invasive neuromodulation technique that enhances vestibular inputs via stochastic resonance, thereby improving postural stability. However, it remains unknown whether nGVS can ameliorate virtual reality (VR)-induced visual-vestibular conflict, which arises from an incongruence between moving visual cues and the absence of corresponding vestibular motion signals during quiet standing. The underlying neural-muscular mechanisms through which nGVS may modulate such conflict warrant clarification. This study aimed to investigate the effects of nGVS on postural stability, muscle activation, and cortical activation in healthy individuals during upright stance under different visual conditions.

methodsThirty healthy young adults participated in this study. Six standing trials involving 3 visual conditions (eyes-open, eyes-closed, VR) and 2 vestibular stimulation conditions (nGVS and sham stimulation) were randomly allocated to each participant. nGVS was delivered via electrodes placed over bilateral mastoid processes. A synchronized multimodal assessment was conducted, using force plates to measure the center of pressure (COP), surface electromyography to record muscle activity, and functional near-infrared spectroscopy to monitor hemodynamic responses in the frontoparietal cortex.

resultsCompared to sham stimulation, nGVS significantly improved postural stability and hip muscle co-activation under VR perturbation, as evidenced by reduced COP-related parameters (ps < 0.05), decreased muscle activity in the bilateral rectus femoris (left: p = 0.003; right: p = 0.018), left biceps femoris (p = 0.020), and reduced co-contraction indices (left: p = 0.026; right: p = 0.027). In the VR condition, nGVS concurrently leaded to significantly lower dorsolateral prefrontal cortex activation (left: p = 0.038; right: p = 0.047) and higher supramarginal gyrus activation (left: p = 0.048; right: p = 0.029).

conclusionsnGVS effectively mitigated VR-induced sensory conflict and enhanced postural stability. The underlying mechanism may involve the induction of stochastic resonance to optimize vestibular processing and multisensory integration, thereby reducing reliance on the hip strategy.

trial registrationChinese Clinical Trial Registry (ChiCTR# 2300078910); Date of registration: December 20th, 2023.

Indexed as

Postural BalanceVestibular SystemVestibule, LabyrinthVirtual RealityAdultElectric StimulationElectromyographyFemaleHumansMaleMuscle, SkeletalYoung AdultCenter of pressureFunctional near-infrared spectroscopyNoisy galvanic vestibular stimulationSensory conflictStochastic resonanceSurface electromyographyVirtual reality

Identifiers

PMID41821043
PMCPMC13097568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.