ArticleRespiratory research2026
Association between anti-citrullinated peptide antibodies and subclinical interstitial lung disease in community-dwelling adults: the multi-ethnic study of atherosclerosis.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRheumatoid arthritis-associated autoantibodies have been associated with interstitial lung abnormalities (ILA) among community-dwelling adults. We aimed to determine whether greater numbers of positive anti-citrullinated protein antibodies (ACPAs) are associated with ILA in community-dwelling adults.
methodsWe performed a period cross-sectional study. We measured 29 ACPAs via Bio-Plex bead array (2003–2005) and ILA on full-lung CTs (2010–2012) in 868 participants enrolled in the Multi-Ethnic Study of Atherosclerosis. A positive ACPA was defined as titer > 75th percentile. We used generalized additive and logistic regression models to examine associations between number of positive ACPA and ILA and tested for effect modification by race/ethnicity.
resultsIn an adjusted model, each 1 unit increase in log-transformed number of positive ACPA was associated with a 17% decrease in odds of ILA (OR 0.83, 95% CI 0.68–1.01). Race/ethnicity modified the association between log-transformed number of positive ACPA and ILA (interaction p-value 0.03), such that each 1 unit increase in log-transformed number of positive ACPA was associated with a 39% decrease in the adjusted odds of ILA among African American participants (OR 0.61, 95% CI 0.37–0.99) and a 42% decrease in the adjusted odds of ILA among Hispanic participants (OR 0.58, 95% CI 0.36–0.91). There was no significant association between log-transformed number of positive ACPA and ILA among White or Chinese American participants.
conclusionsIn this large population-based multi-ethnic study, an expanded ACPA repertoire was associated with a lower burden of ILA on CT, especially among African American and Hispanic participants.
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