ArticleBMC psychology2026
Social support and maternal caregiving burden in families of children with Angelman syndrome in China: the mediating role of self-stigma.
Article in BMC psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRearing a child with Angelman syndrome (AS) poses significant maternal burden. This study examines whether social support–including family, friends, and significant other dimensions–is associated with maternal caregiving burden among primary caregivers of children with AS in mainland China, and whether caregivers’ self-stigma mediates this relationship.
methodsIn the cross-sectional study, a total of 281 primary caregivers (263 mothers) of children with AS in China completed a questionnaire assessing sociodemographic factors, social support (MSPSS-12), self-stigma (ASS-22), and caregiving burden (ZBI-22). All participants were members of the Chinese Angelman Syndrome Organization. Statistical analyses, including multivariable regression and mediation models, were conducted in R 4.2.2. We employed nonparametric bootstrapping for sensitivity analyses.
resultsIn the composite model, lower social support was associated with higher self-stigma, which fully mediated its effect on higher caregiving burden. In the disaggregated model, lower family-support was directly and indirectly associated with higher caregiving burden, with self-stigma serving as a partial mediator. The effect of friends-support on caregiving burden was inconclusive, while significant-others-support was not significant.
conclusionThis study identifies self-stigma as a significant mediator in the relationship between social support and maternal caregiving burden, with family-support emerging as the dimension most strongly associated with these outcomes. These findings highlight the potential value of interventions aimed at enhancing family-support and reducing self-stigma to improve the well-being of mothers of children with AS in China.
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