Evidence map›Paper›PMID 41820880›Full record

ArticleBMC cardiovascular disorders2026

Quantitative flow ratio for assessment of donor vessel in patients with chronic total occlusions.

Xinjian Li, Juntao Duan, Lin Mi, Liyuan Tao, Xinye Xu, Guisong Wang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xinjian Li *Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Juntao Duan *Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Lin MiDepartment of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Liyuan TaoClinical Epidemiology Research Center, Peking University Third Hospital, Beijing, China.
Xinye XuDepartment of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. leaftonks@126.com.
Guisong WangDepartment of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. guisongwang@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic total occlusion (CTO) is a challenging subset of coronary artery disease characterized by complete vessel obstruction and development of collateral circulation. In CTO patients, donor vessels supplying collateral flow may be at risk of functional ischemia. Functional assessment of these donor vessels can provide valuable insights into the ischemic status. Quantitative flow ratio (QFR) is an angiography-based method for the functional assessment of coronary arteries and Murray-law based QFR (µQFR) requires only a single coronary projection, enhancing its applicability. This study primarily aims to investigate the agreement between µQFR and 3D-QFR for functional assessment of donor vessels in CTO patients.

methodsThis single-center retrospective study enrolled patients with a single-vessel CTO lesion between January 2015 and June 2023. Both µQFR and 3D-QFR were used to assess the function of the predominant collateral donor artery following standard protocol.

resultsA total of 336 CTO patients were included. There was a good correlation between µQFR and 3D-QFR (r = 0.947, p < 0.001). The diagnostic accuracy was 96.1% (95% CI, 93.5%-97.9%). ROC curve analysis revealed an AUC of 0.984 (95% CI, 0.971-0.997) for µQFR in estimating 3D-QFR.

conclusionsµQFR has good correlation and agreement with standard 3D-QFR for the functional assessment of donor vessels in CTO patients.

Indexed as

Collateral CirculationCoronary AngiographyCoronary CirculationCoronary OcclusionCoronary VesselsAgedBlood Flow VelocityChronic DiseaseFemaleHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesChronic total occlusionsDonor vesselQuantitative flow ratio

Identifiers

PMID41820880
PMCPMC13094110

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