Evidence map›Paper›PMID 41820814›Full record

SynthesisPsycho-oncology2026

Mindfulness-Based Interventions for Depression, Anxiety, and Stress in Adults With Cancer: A Stratified Subgroup Meta-Analysis.

Kenni Wojujutari Ajele, Erhabor Sunday Idemudia

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kenni Wojujutari AjeleFaculty of Humanities, North-West University, Mafikeng, South Africa.ORCID https://orcid.org/0000-0002-1796-4848
Erhabor Sunday IdemudiaFaculty of Humanities, North-West University, Mafikeng, South Africa.ORCID https://orcid.org/0000-0002-5522-7435

Funding

Funding Open access funding was provided by North-West University, South Africa.North-West University
6 · The paper itself

Abstract

backgroundPsychological distress, including depression, anxiety, and stress, is highly prevalent among adults with cancer. Mindfulness-based interventions (MBIs), such as Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), are increasingly used to address these symptoms. However, no prior review has comprehensively stratified MBI effects across intervention types, symptom domains, cancer populations, and geographic regions.

aimsTo evaluate the effectiveness of MBIs, including standard and adapted formats, on depression, anxiety, and stress in adults with cancer.

methodsA systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted in accordance with PRISMA guidelines. Six databases were searched from January 2010 to July 2025. Eligible studies included RCTs comparing MBIs to control conditions in adults with cancer, reporting validated outcomes for depression, anxiety, or stress. Random-effects meta-analyses were performed using Hedges' g, with subgroup analyses by intervention type, duration, geographic region, and cancer type.

resultsAcross 84 effect sizes from 45 RCTs (N = 7395), mindfulness-based interventions were evaluated. MBIs significantly reduced depression (g = -0.92), anxiety (g = -1.06), and stress (g = -1.50). Modified MBIs MBIs demonstrated the largest effects (g = -1.57), followed by MBSR (g = -0.72) and MBCT (g = -0.68). The strongest effects were observed in breast cancer populations (g = -1.48) and in studies conducted in North America (g = -1.21) and Asia (g = -1.07).

conclusionsMindfulness-based interventions (MBIs) were associated with reduced depression, anxiety, and stress in adults with cancer, though heterogeneity was high and evidence was largely from breast cancer trials. MBIs appear scalable, particularly for women with breast cancer, but broader conclusions remain limited. Findings support their inclusion in tailored psychosocial care, with a need for more diverse and rigorously controlled research.

Indexed as

AnxietyDepressionMindfulnessNeoplasmsStress, PsychologicalAdultFemaleHumansRandomized Controlled Trials as Topic

Identifiers

PMID41820814
PMCPMC12982628

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.