ArticleMolecular psychiatry2026
Multivariate relationships between social cognitive performance and functional connectivity during task and rest across schizophrenia spectrum disorders and healthy controls.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Social cognitive deficits are common and impact functional outcomes in people with schizophrenia spectrum disorders (SSDs). Functional brain networks during task and rest show complex relationships with cognition. We aimed to identify relationships between social and non-social cognitive performance and functional connectivity during social processing and at rest across individuals with SSDs and healthy controls. Adults (N = 352; 195 SSDs, 157 controls) completed functional magnetic resonance imaging (fMRI) during the Empathic Accuracy (EA) task and rest, and cognitive assessments. Partial least squares correlation was used to identify latent dimensions (LDs) capturing multivariate relationships between functional connectivity and cognitive measures, evaluated using permutation testing, bootstrapping, and cross-validation. Two significant EA LDs were identified, explaining 73.6 and 9.1% of the variance. EA LD1 captured an association between better performance across cognitive measures and positive connectivity across networks implicated in processing dynamic multimodal and social stimuli. EA LD2 reflected an association between worse EA task performance and stronger positive connectivity between networks implicated in language and social processing. One significant resting-state LD was identified, explaining 85.6% of the variance and capturing an association between better overall cognition and visual, somatomotor, and subcortical connectivity, driven more by the SSD group. Overlapping and divergent connectivity patterns appear to covary with cognitive performance during social processing versus rest across SSDs and healthy controls. Our results support the value of task-based fMRI to identify dimensional functional connectivity patterns associated with particular social cognitive abilities, whereas resting-state connectivity may reflect broader relationships with cognition.
Indexed as
Identifiers
41820637What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.