ReviewMolecular psychiatry2026
Pursuing the elusive biosignature for suicide: a decennial update.
Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gene alteration in human brain suggests genetic and epigenetic roots of major depression.Nature medicine · 2026Article
- In the Search for Suicide Signatures, Phenotype Matters.Translational psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Suicide is the second leading cause of death for American adolescents and young adults and is transdiagnostic. Suicide risk is impacted by genetic and both distal and proximal environmental factors, particularly stress exposures. This review encompasses the past 10 years of research comparing biological measures between suicide decedents and control decedents and identifies studies focused on stress-related biological pathways, inflammation, neuroplasticity, and the serotonergic system as candidate contributors. Inclusion criteria for studies aimed to maximize confidence that reported biological differences are specific to suicide and independent of confounding psychiatric comorbidity, addressing ambiguity in previous work. The review revealed evidence for alterations in stress-related biological systems and decreased serotonergic tone among suicide decedents. Methodological and conceptual advances over the past decade have driven a shift from hypotheses-driven to data-driven approaches, including genomic, transcriptomic and methylomic analyses. While multi-omic studies have the potential to identify mechanistic molecular targets, to date findings lack interpretability. This review highlights the need for research in larger samples, across multiple brain areas, and in specific cell types to fill a gap in system biology-guided multi-omic studies. Lastly, incorporating poly-environmental stress exposure (exposomic) models in suicide postmortem research may elucidate mechanisms linking environmental stress and biological measures, potentially increasing the reproducibility of postmortem suicide studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.