ArticleThe Journal of antibiotics2026
Discovery of diketopiperazine alkaloids from an endophytic Kitasatospora sp. by heterologous expression.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Heterologous expression of a tRNA-dependent cyclodipeptide synthase (CDPS)-containing biosynthetic gene cluster from the endophytic Kitasatospora sp. CPCC204717 resulted in the discovery of two novel diastereoisomeric 3-hydroxy-2-oxindole diketopiperazine alkaloids (1-2) along with three known congeners cyclo-L-tryptophan-L-tryptophan (3), guanitrypmycin C3-2 (4), and guanitrypmycin C3-1 (5). Their structures were elucidated by extensive spectroscopic analyses combined with ECD calculations. Compound 2 exhibited antibacterial activities against Staphylococcus aureusa while 1-5 displayed binding affinities and inhibitory effects against CYP121.
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