Evidence map›Paper›PMID 41820589›Full record

ArticleNpj mental health research2026

A multi-omics analysis of gut bacteriome, virome, and serum metabolome in bipolar depression.

Lingzhuo Kong, Yifan Zhuang, Boqing Zhu, Huaizhi Wang, Yiqing Chen, Yuting Shen, Xinhua Feng, Shaohua Hu, Jianbo Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj mental health research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lingzhuo Kong *Department of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yifan Zhuang *Department of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Boqing Zhu *Department of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Huaizhi Wang *Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Yiqing ChenDepartment of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yuting ShenAffiliated Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China.
Xinhua FengDepartment of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Shaohua HuDepartment of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. dorhushaohua@zju.edu.cn.
Jianbo LaiDepartment of Psychiatry, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. laijianbo@zju.edu.cn.

Funding

Key Research & Development Program of Zhejiang Province 2024C03098, 2025C02109National Key Research and Development Program of China 2023YFC2506200, 2023YFC2506203National Natural Science Foundation of China 82571735, 82471542Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2023001B
6 · The paper itself

Abstract

The involvement of microbiota-gut-brain axis in bipolar disorder (BD) has been uncovered, yet the specific tripartite interplay between the gut bacteriome, virome, and serum metabolome remains to be elucidated. We conducted a cross-sectional multi-omics analysis on 90 drug-free patients with bipolar depression and 30 healthy controls. A significant between-group difference in gut bacterial α-diversity was observed. Non-parametric test revealed 1929 bacterial and 134 viral species with significant inter-group difference, among which 249 bacterial and 7 viral species remained significant after FDR correction (P

Identifiers

PMID41820589
PMCPMC12982605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.