Reviewnpj metabolic health and disease2026
Enteric nervous system in exercise physiology: a microbiota-neural interface.
Review in npj metabolic health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Exercise responses vary widely among individuals, yet the biological basis of this variability remains poorly understood. Microbiota-derived metabolites operate on timescales of hours to days, making them insufficient to explain rapid gastrointestinal and performance changes that emerge within minutes of exercise. We propose that the enteric nervous system (ENS) fills this regulatory gap by integrating mechanical, immune, and microbial signals in real time. We review evidence that the ENS modulates gut motility, barrier function, and microbial ecology during exercise, engages in bidirectional crosstalk with the microbiota, and relays gut-derived signals to muscle and brain via neural and humoral routes. We further introduce the concept of neuro-enteric phenotypes to account for inter-individual differences in exercise tolerance and adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.