Evidence map›Paper›PMID 41820405›Full record

ArticleNPJ Parkinson's disease2026

Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease.

Zhinan Ye, Yuchen Lin, Yangguang Lu, Zihao Wu, Baoyi Zhu, Qiaoqiao Jin, Yang Zhang, Zhuoyu Chen, Xinyi Yuan, Zihan Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Zhinan Ye *Department of Neurology, Taizhou Municipal Hospital, Taizhou, China.
Yuchen Lin *The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Yangguang Lu *The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Zihao WuThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Baoyi ZhuThe School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Qiaoqiao JinThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Yang ZhangThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Zhuoyu ChenThe Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Xinyi YuanThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Zihan YuanThe Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Ziyu YangThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Suwen HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yiyun WengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wengyiyun2012@126.com.
Dehao YangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. dehao_yang@zju.edu.cn.

Funding

the National Natural Science Foundation of China 82302081the National Undergraduate Innovation and Entrepreneurship Training Program of China 202510343038the Science and Technology Plan Project of Taizhou 25ywb102the Zhejiang Provincial Natural Science Foundation of China LQ24H090003
6 · The paper itself

Abstract

This study investigated the genetic and phenotypic associations of the glymphatic system and brain characteristics with Parkinson's disease (PD) and developed an imaging-derived early prediction model. In a case-control analysis of 118 PD patients and 58 matched controls, a lower analysis along the perivascular space (ALPS) index (odds ratio [OR] = 0.049, 95% confidence interval [CI]: 0.013-0.181) and elevated free water content, particularly in the temporal lobe (OR = 5.603, 95% CI: 3.093-10.150), were both associated with PD. Their combination provided the highest predictive accuracy for PD (area under the curve (AUC) = 0.818, 95% CI: 0.750-0.886). Furthermore, Mendelian randomization analysis demonstrated positive causal effects of frontal, occipital, parietal, and temporal lobes on PD risk (OR > 1, p ≤ 0.05). These findings indicate that glymphatic dysfunction and specific brain alterations are associated with PD, and that combining them may improve early prediction strategies.

Identifiers

PMID41820405
PMCPMC13121599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.