Evidence map›Paper›PMID 41820379›Full record

ArticleNature communications2026

The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis.

Li Chen, Liman Diao, Jiaqi Ruan, Yanli Deng, Kai Zhang, Yan Guan, Ling Li, Min Liang, Lina Peng, Jiayi Shi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Li Chen *Shanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Liman Diao *Shanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Jiaqi RuanShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Yanli DengShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Kai ZhangShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Yan GuanShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Ling LiSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Min LiangShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Lina PengShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Jiayi ShiShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Shilong ZhangShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Minqing LiuShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Yupeng LiShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Zhilei MaoShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Wenxiu WangShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Hong-Quan YangShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China.ORCID http://orcid.org/0000-0001-6215-2665
Tongtong GuoShanghai Key Laboratory of Plant Molecular Sciences, Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development, College of Life Sciences, Shanghai Normal University, Shanghai, China. ttguo@shnu.edu.cn.ORCID http://orcid.org/0000-0003-0462-3929

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32000183National Natural Science Foundation of China (National Science Foundation of China) 32370262National Natural Science Foundation of China (National Science Foundation of China) 32470254
6 · The paper itself

Abstract

DNA double-strand break (DSB) represents the most severe form of DNA damage, and both defective and hyperactive repair can compromise genome stability. It is known that blue light promotes DSB repair by cryptochromes (CRYs)-enhanced STRUCTURAL MAINTENANCE OF CHROMOSOME 5/6 (SMC5/6) complex recruitment via ALTERATION/DEFICIENCY IN ACTIVATION 2B (ADA2b). Here, we report a negative regulatory module consisting of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), an E3 ubiquitin ligase acting as a central repressor of photomorphogenesis, and ADA2b, a pivotal positive regulator of DNA repair, mediates light regulation of DSB repair. Light induces the accumulation of ADA2b, while COP1 physically interacts with ADA2b to mediate its ubiquitination and degradation through the 26S proteasome. The cop1-4 mutant exhibits enhanced DNA damage resistance under various light conditions, whereas the red/far-red photoreceptor phytochrome A and B (phyA/phyB) mutant displays hypersensitivity under red light. COP1 lies upstream of ADA2b but downstream of CRYs and phyB to regulate DNA repair. These findings reveal a pivotal role for the COP1-ADA2b module in CRYs- and phyA/phyB-mediated light regulation of DSB repair. The antagonistic regulation of ADA2b stability by photoreceptors and COP1 may dynamically calibrate DNA repair activity to maintain genome stability and optimize plant growth according to the fluctuating light conditions.

Indexed as

ArabidopsisArabidopsis ProteinsDNA Breaks, Double-StrandedDNA RepairUbiquitin-Protein LigasesBlue LightCryptochromesGene Expression Regulation, PlantLightMutationPhytochrome BProteasome Endopeptidase ComplexUbiquitinationArabidopsis ProteinsAT2G32950 protein, ArabidopsisCryptochromesPHYB protein, ArabidopsisPhytochrome BProteasome Endopeptidase ComplexUbiquitin-Protein Ligases

Identifiers

PMID41820379
PMCPMC13125681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.