Evidence map›Paper›PMID 41820356›Full record

ArticleNPJ breast cancer2026

The landscape of B and plasma cells in breast cancer: insights from single-cell and spatial transcriptomics.

Xing Cai, Jinru Yang, Wenzheng Wang, Xiaolu Zhan, Xiaohan Chen, Dongchen Ji, Kexin Liu, Xue Li, Yuxin Zhang, Cheng Qian and 3 more

Abstract read
In one paragraph

Article in NPJ breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xing Cai *Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Jinru Yang *Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, PR China.
Wenzheng Wang *Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Xiaolu ZhanDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Xiaohan ChenDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Dongchen JiDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Kexin LiuDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Xue LiDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Yuxin ZhangDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China.
Cheng QianDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China. qiancheng@ems.hrbmu.edu.cn.
Xiaofang DaiHubei Key Laboratory of Precision Radiation Oncology, Wuhan, PR China. 2003xh1047@hust.edu.cn.
Guang YangDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China. guangyang@hrbmu.edu.cn.
Tong LiuDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, PR China. liutong@hrbmu.edu.cn.

Funding

National Natural Science Foundation of China: General Program 82173184National Natural Science Foundation of China: General Program 82272872National Natural Science Foundation of China: Outstanding Youth Program 82322048Natural Science Foundation of Heilongjiang Province of China: Distinguished Youth Program JQ2023H004
6 · The paper itself

Abstract

Tumor-associated B (TAB) cells and plasma cells are increasingly recognized as key components of the tumor microenvironment; however, their heterogeneity and functional roles in breast cancer remain incompletely understood. Here, by integrating publicly available single-cell RNA (scRNA) sequencing datasets with newly generated scRNA-seq and single-cell BCR sequencing data from 79 samples across 35 patients, we constructed a comprehensive atlas of B and plasma cells in breast cancer. Systematic analyses of transcriptional profiles, clonal expansion, spatial distribution, and cell-cell interactions revealed 21 distinct subsets of TAB cells with substantial functional diversity. Among them, two tumor-enriched populations, CD200

Identifiers

PMID41820356
PMCPMC13121808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.