ArticleNature communications2026
Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
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Authors and funding
60 authors.
Hiroyuki UedaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Tomoya KubotaDepartment of Clinical Laboratory and Biomedical Sciences, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0003-1004-8537
Risa GotoDepartment of Clinical Laboratory and Biomedical Sciences, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takafumi OjimaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0003-1197-0574
Kotaro OgawaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Kyuto SoneharaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-4536-1761
Shinichi NambaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-7486-3146
Tatsuhiko NaitoDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-2779-4600
Qingbo WangDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-9110-5830
Shingo KonnoDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, Japan.
Makoto SamukawaDepartment of Neurology, Kindai University Faculty of Medicine, Sakai, Japan.
Naoki KawaguchiDepartment of Neurology, Neurology Chiba Clinic, Chiba, Japan.
Takashi KimuraDepartment of Neurology, Hyogo Medical University, Nishinomiya, Japan.ORCID http://orcid.org/0000-0002-0401-7227
Takamichi SugimotoDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan.ORCID http://orcid.org/0000-0003-3652-0772
Hiroyuki MuraiDepartment of Neurology, International University of Health and Welfare, Narita, Japan.ORCID http://orcid.org/0000-0003-1612-1440
Takemori YamawakiDepartment of Neurology, Fukushima Seikyo Hospital, Hiroshima, Japan.
Kenichi KaidaDepartment of Neurology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Daiki TokuyasuDepartment of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Manato YasudaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0002-2876-3857
Hiroyuki AkamineDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yosuke OnishiDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yosuke OgawaDepartment of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5049-5764
Yuya ShiraiDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-0518-9020
Ryuya EdahiroDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0001-5009-6408
Kenichi YamamotoDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0001-9594-7050
Hideki NagataDepartment of General Thoracic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Naoko OseDepartment of General Thoracic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Jun TakayamaCenter for Advanced Intelligence Project, RIKEN, Tokyo, Japan.
Ken SuzukiDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0003-1065-3593
Shinichi HigashiueTokushukai Group, Shonan Kamakura General Hospital, Tokyo, Japan.
Shuzo KobayashiTokushukai Group, Shonan Kamakura General Hospital, Tokyo, Japan.
Hiroki YamaguchiDepartment of Hematology, Nippon Medical School, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0571-7495
Yasushi OkazakiDiagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3241-5502
Naoyuki MatsumotoDiagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Kenta MotomuraAso Iizuka Hospital, Fukuoka, Japan.
Hidenobu KogaAso Iizuka Hospital, Fukuoka, Japan.
Japan Myasthenia Gravis Registry
BioBank Japan Project
Tohoku Medical Megabank Project Study Group
Koichi MatsudaDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Gen TamiyaCenter for Advanced Intelligence Project, RIKEN, Tokyo, Japan.
Masayuki YamamotoGraduate School of Medicine, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0002-9073-9436
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4827-6404
Takashi KadowakiToranomon Hospital, Tokyo, Japan.
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akiko OhnoDepartment of Clinical Laboratory and Biomedical Sciences, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Tatsusada OkunoDepartment of Neurology, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Eiichi MoriiDepartment of Pathology, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Hideki MochizukiDepartment of Neurology, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-0874-7542
Yuriko NaganeDepartment of Neurology, Hanamaki General Hospital, Hanamaki, Japan.
Naoya MinamiDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Akiyuki UzawaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masayuki MasudaDepartment of Neurology, Tokyo Medical University, Tokyo, Japan.
Shigeaki SuzukiDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0003-4388-4574
Iichiro ShimomuraDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Yasushi ShintaniDepartment of General Thoracic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-2540-5288
Kimiaki UtsugisawaDepartment of Neurology, Hanamaki General Hospital, Hanamaki, Japan.ORCID http://orcid.org/0000-0001-9373-8167
Masanori P TakahashiDepartment of Clinical Laboratory and Biomedical Sciences, Graduate School of Medicine, The University of Osaka, Suita, Japan. mtakahas@sahs.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-5513-5012
Yukinori OkadaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-0311-8472
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds ratio [OR] = 1.31, P = 1.7×10
Indexed as
Myasthenia GravisThymomaThymus NeoplasmsAdultAgedEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanMaleMiddle AgedMultiomicsPolymorphism, Single NucleotideTelomeraseTelomeraseTERT protein, human
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