SynthesisTranslational psychiatry2026
Consistent cortico-basal ganglia-cerebellar activation in early motor sequence learning: a systematic review and meta-analysis.
Synthesis in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Temporal dynamics of ipsilateral corticospinal excitability during the motor learning process of a complex manual task.Experimental brain research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to systematically investigate activation in brain regions during early-stage motor sequence learning (MSL) and to identify convergent neural activation patterns, thereby advancing our understanding of the neural mechanisms underlying MSL.
methodsThis meta-analysis integrated functional magnetic resonance imaging (fMRI) data from 12 studies (219 participants) using the serial reaction time task (SRTT) paradigm, applying anisotropic effect-size seed-based d mapping (AES-SDM) to identify common brain activation regions underlying MSL. After the primary meta-analysis, subgroup analyses were conducted on the young adult group, implicit learning group, and bimanual/right-hand task group to investigate the specific effects of age and task type on brain region activation in MSL. Additionally, an independent fMRI dataset from 64 healthy participants performing SRTT was used to validate the meta-analysis results.
resultsWe identified convergent activations during SRTT in cortico-basal ganglia-cerebellar circuit, encompassing the supplementary motor area (SMA), precentral gyrus (PreCG), rolandic operculum (ROL), and other cortical regions, alongside basal ganglia and cerebellum, collectively underscoring their critical roles in early-stage MSL. Subgroup analyses revealed age- and task-related modulation of neural activation patterns. Results were largely replicated in the independent validation dataset.
conclusionsOur findings provide reliable evidence for the involvement of a cortico-basal ganglia-cerebellar circuit in MSL. SIGNIFICANCE: Our meta-analysis contributes to unraveling the brain activation patterns underlying early-stage MSL, offering insights for clinical interventions in motor dysfunction rehabilitation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.