ArticleMagnetic resonance in medicine2026
Double Asymmetric Spin Echo EPI (dASE-EPI) Enables fMRI of the Entire Rat Brain at 9.4 T.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeDevelopment and evaluation of a double asymmetric spin echo planar imaging (dASE-EPI) sequence to balance sensitivity to blood oxygenation level-dependent (BOLD) contrast with mitigation of susceptibility-induced intravoxel spin dephasing in ultra high-field rodent brain imaging.
methodsA dASE-EPI pulse sequence was implemented and resting-state BOLD fMRI was acquired in the rat brain. Data acquired with dASE-EPI were compared to conventional gradient-recalled EPI. Functional connectivity analyses were performed to assess detection of established networks and to evaluate signal recovery in regions affected by susceptibility (e.g., amygdala, hypothalamic nuclei).
resultsdASE-EPI was found to provide BOLD sensitivity that was non-inferior to conventional GRE-EPI while substantially reducing susceptibility-related signal loss. Established functional networks including the bilateral insular, bilateral sensory, and default mode network were reliably detected with dASE-EPI. Functional connectivity of the amygdala, which was obscured in GRE-EPI, was recoverable with the proposed sequence.
conclusionThe proposed dASE-EPI pulse sequence is a viable solution when studying brain regions which suffer from severe susceptibility artifacts.
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