Evidence map›Paper›PMID 41820220›Full record

ArticleMagnetic resonance in medicine2026

Free-Breathing Magnetization Transfer Imaging of the Lung at 0.55 T Using bSTAR.

Alexandra Braun, Grzegorz Bauman, Maurice Pradella, Jonathan Röcken, Katrin E Hostettler, Oliver Bieri

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Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Alexandra BraunDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.ORCID 0009-0009-2153-9391
Grzegorz BaumanDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.ORCID 0000-0001-6972-0776
Maurice PradellaDepartment of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Jonathan RöckenClinics of Respiratory Medicine, University Hospital Basel, Basel, Switzerland.
Katrin E HostettlerClinics of Respiratory Medicine, University Hospital Basel, Basel, Switzerland.
Oliver BieriDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.ORCID 0000-0002-6755-5495

Funding

Swiss National Science Foundation 320030_219186
6 · The paper itself

Abstract

purposeTo develop a clinically applicable method for magnetization transfer (MT) imaging of the lung at 0.55 T.

methodsMT imaging of the chest was explored in healthy volunteers at 0.55 T using a self-gated 3D half-radial dual-echo balanced steady-state free precession sequence (bSTAR), a 2D multi-slice gradient echo method (GRE) acquired in end-expiratory breath-hold, and a self-gated 3D half-radial single-echo ultra-short TE (UTE) approach. MT contrast relied on RF pulse prolongation for bSTAR and on pulsed off-resonance irradiation for UTE and GRE. Data reconstruction from the self-gated scans was performed offline and for the end-expiratory tidal phase using a compressed sensing algorithm. MT ratio (MTR) maps were derived from an MT-weighted and a non-MT-weighted scan and took 8:32 min for bSTAR, 17:16 min for UTE, and 0:48 min for GRE. In addition, patients with pulmonary diseases underwent bSTAR MTR imaging.

resultsMT imaging was successfully performed in all volunteers with highly similar average MTR values for the lung of 28.8 pu (UTE), 29.4 pu (GRE), and 30.7 pu (bSTAR). In terms of resolution, however, bSTAR clearly outperformed both UTE and GRE variants. Finally, MTR imaging with bSTAR demonstrated high reproducibility in volunteers and showed substantially different MTR values for patients with various pulmonary diseases.

conclusionAt 0.55 T, MT-sensitized bSTAR offers in vivo high-resolution free-breathing MTR imaging of the entire lung in clinically acceptable scan times and shows high reproducibility. Initial results suggest that MTR imaging at 0.55 T may potentially serve as a noninvasive biomarker for investigating and differentiating pulmonary diseases.

Indexed as

LungLung DiseasesMagnetic Resonance ImagingAdultAlgorithmsFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedImaging, Three-DimensionalMaleMiddle AgedReproducibility of ResultsRespirationbalanced steady‐state free precessionbSTARlow fieldlungmagnetization transfer

Identifiers

PMID41820220
PMCPMC13156434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.