SynthesisInternational journal of dental hygiene2026
The Effect of Chlorhexidine Mouthwash on Blood Pressure: A Systematic Review and Meta-Analysis.
Synthesis in International journal of dental hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Should chlorhexidine mouthwash be a concern for blood pressure in dental patients?Evidence-based dentistry · 2026Article
- Research Trends in Antimicrobial Oral Hygiene Products, the Oral Microbiome, and Dental Biofilm: A Bibliometric Analysis (2006-2025).Antibiotics (Basel, Switzerland) · 2026Article
- The Journey of Oral Hygiene: The Past, the Present, the Future.Journal of periodontal research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
aimThis study evaluated the effect of rinsing with a chlorhexidine containing mouthwash (CHX-MW) on blood pressure (BP), as compared to rinsing with a control MW or no MW, based on (randomised) controlled trials and observational studies in humans. PROSPERO CRD42020222495. MATERIALS AND
methodsThe PubMed-MEDLINE and COCHRANE-CENTRAL databases were searched to identify eligible studies that had been published as of December 2024. Studies evaluating the effect of CHX-MW on human BP were included. A descriptive analysis of the selected studies and a meta-analysis was performed.
resultsSearching identified 100 unique studies; five studies fulfilled all inclusion criteria and could be analysed. The descriptive analysis demonstrated that both systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly increased after the use of CHX-MW in two of the included studies. The meta-analysis (MA) showed no significant difference of means (DiffM) based on end scores between CHX-MW and controls for SBP (DiffM = 1.56, P=0.17; 95% CI [-0.67; 3.80]) and DBP (DiffM = -0.10, P=0.91; 95% CI [-1.99; 1.78]).
conclusionFor patients to whom the use of CHX-MW has been recommended, there is a moderate level of confidence that any change in BP due to the use of the antiseptic MW is insignificant or very small. The clinical importance of this BP elevation is estimated to be negligible.
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Registered trials
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