ReviewTrends in biotechnology2026
Engineering Salmonella as an immune-metabolic modulator of the tumor microenvironment.
Review in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microbiome and cancer: mechanistic insights, diagnostic potential, and therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Engineering bacteria as cancer therapeutics is gaining mounting attention due to the remarkable success in recent preclinical studies against several solid tumor models. Among the bacteria used, Salmonella stands out due to its inherent tumor localization ability, potential to activate the immune system, and ability to cause tumor regression, while having an easily editable genetic system. Here, we gather information on the mechanisms that enable Salmonella to stimulate the immune system and exert antitumor effects. We also address the genetic manipulation approaches adopted to reduce virulence, enhance tumor colonization, and equip Salmonella with the ability to deliver immunotherapeutic payloads, along with recent advances made in tumor metabolome rewiring. Finally, we propose the challenges associated with bacteria-based cancer therapy.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.