Evidence map›Paper›PMID 41820080›Full record

ReviewTrends in genetics : TIG2026

RNA polymerase II: the elephant in the room.

Steven Henikoff, Steven Hahn

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. KAS-CUT&Tag for direct mapping of transcription bubbles.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven HenikoffBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: steveh@fredhutch.org.
Steven HahnBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Funding

Mechanisms of transcriptional regulation and transcription factor specificityR35GM140823 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Steven M Hahn · 2021 to 2026
$6.6M
NIGMS NIH HHS R35 GM140823
6 · The paper itself

Abstract

How genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct target of more than 100 protein kinases, a previously underappreciated mechanism for generating epigenetic complexity.

Indexed as

RNA Polymerase IIAnimalsEpigenesis, GeneticHistonesHumansPhosphorylationProtein KinasesTranscription FactorsTranscription, GeneticHistonesProtein KinasesRNA Polymerase IITranscription Factorscondensatesintrinsically disordered region (IDR)phosphorylationPol II CTDreceptor kinasestranscription factors

Identifiers

PMID41820080
PMCPMC13242782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.