Trial reportRenal failure2026
Comparative efficacy of low-concentration trisodium citrate and low-concentration heparin for locking central venous hemodialysis catheters: a randomized controlled study.
Trial report in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central venous catheters (CVCs) are used in hemodialysis patients when arteriovenous fistulas (AVFs) or grafts (AVGs) are not feasible. Catheter-locking anticoagulants (CLAs), such as low-concentration trisodium citrate (TSC) and unfractionated heparin (UFH), are used to prevent catheter dysfunction (CD), but comparative data on their safety and efficacy - especially at low concentration remain limited. This study evaluates the efficacy of low-concentration TSC versus low-concentration UFH as CLAs in hemodialysis CVCs. Patients undergoing hemodialysis were randomly allocated to receiving either 5% TSC or UFH 1000 U/mL as CLAs. The primary outcome was the CD rate. Secondary outcomes encompass catheter-related bloodstream infection (CRBSI), exit site infection (ESI), bleeding events, and mortality at 180 days. A total of 204 hemodialysis patients were randomized to receive either 5% trisodium citrate or 1,000 U/mL unfractionated heparin as catheter-locking anticoagulants. The CD rates at 180 days were 1.11 and 1.73 per 1,000 catheters-days for TSC and UFH, respectively, yielding an incidence rate ratio of 1.55 (95% CI: 0.72-3.45),
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