ArticleBritish journal of clinical pharmacology2026
Population pharmacokinetics and Monte Carlo simulation of Cefepime in paediatric and Young adult bone marrow transplant patients.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Population pharmacokinetics and Monte Carlo simulation of Cefepime in paediatric and Young adult bone marrow transplant patients.British journal of clinical pharmacology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
aimsTo develop a population pharmacokinetic (PopPK) model of cefepime in paediatric and young adult BMT patients, identify clinical predictors of variability in cefepime clearance and simulate dosing strategies to optimize therapeutic target attainment.
methodsThis PopPK analysis pooled data from two prospective studies, including 97 BMT patients aged 1 month to 30 years with 252 cefepime plasma concentrations. The final model was validated with goodness-of-fit plots, bootstrap analysis and prediction-corrected visual predictive checks. Monte Carlo simulations assessed the probability of target attainment (PTA) for various dosing regimens, targeting 100% of the dosing interval during which free drug concentrations exceed the minimum inhibitory concentration (100% fT>MIC), across a range of estimated glomerular filtration rates (eGFR) and MICs.
resultsA two-compartment model with first-order elimination best described the data. The most predictive covariate for cefepime clearance was eGFR estimated using a combined creatinine-cystatin C equation (eGFR
conclusionsThis study presents the first cefepime PopPK model tailored to paediatric and young adult BMT recipients, identifying eGFR
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