Evidence map›Paper›PMID 41819842›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Suppression of In Vitro Epileptiform Activity by GABA Transaminase Inhibition Is Dependent on GABA

Gabriela Holmes-Léon, Ning Li, Joe Albrecht, Gregory S Newkirk, Amber Nolan, Christopher B Ransom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriela Holmes-LéonEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108.
Ning LiEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108.
Joe AlbrechtEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108.
Gregory S NewkirkEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108.
Amber NolanEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108.ORCID https://orcid.org/0000-0002-0139-0974
Christopher B RansomEpilepsy Center of Excellence, VA Puget Sound, Seattle, Washington 98108 cbr5@uw.edu.

Funding

BLRD VA I01 BX000807BLRD VA I01 BX002745
6 · The paper itself

Abstract

Many antiepileptic drugs act by modulation of ionotropic GABA

Indexed as

4-Aminobutyrate TransaminaseEpilepsyGABA Plasma Membrane Transport ProteinsReceptors, GABA-B4-AminopyridineAnimalsAnticonvulsantsBaclofenDose-Response Relationship, DrugGABA-B Receptor AntagonistsHippocampusIn Vitro TechniquesMaleMiceMice, Inbred C57BLMice, Knockout4-Aminobutyrate Transaminase4-AminopyridineAnticonvulsantsBaclofenCGP 55845AGABA-B Receptor AntagonistsGABA Plasma Membrane Transport ProteinsPhosphinic AcidsPropanolaminesReceptors, GABA-BVigabatrinepilepsyGABAB receptorsGIRK channelseizuretonic inhibitionvigabatrin

Identifiers

PMID41819842
PMCPMC13086248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.