Evidence map›Paper›PMID 41819831›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Single-Domain Antibody Probe with Low Renal Uptake for Claudin 18.2-Targeted PET Imaging of Gastric Cancer: Preclinical and Pilot Clinical Evaluations.

Meng Zheng, Haoqun Ma, Tao Xu, Huiwen Mu, Qingfeng Liu, Kaijie Zhang, Yicong Bian, Hua Zhang, Wei Li, Bin Zhang and 5 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Meng ZhengDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Haoqun MaDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Tao XuSmart-Nuclide Biotech, Suzhou, China.
Huiwen MuDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Qingfeng LiuDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Kaijie ZhangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Yicong BianDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Hua ZhangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Wei LiDepartment of Oncology, First Affiliated Hospital of Soochow University, Suzhou, China.
Bin ZhangDepartment of Nuclear Medicine, First Affiliated Hospital of Soochow University, Suzhou, China; and.
Yuanyuan ShanDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Xuanhui PengDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Songbing QinDepartment of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou, China qin92244@163.com 0814wangyan@163.com miaolysuzhou@163.com.
Yan WangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China; qin92244@163.com 0814wangyan@163.com miaolysuzhou@163.com.
Liyan MiaoDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High renal uptake limits the clinical translation of Claudin 18.2 (CLDN18.2) nanobody probes. We aimed to develop and identify a single-domain antibody-based molecular probe to minimize nonspecific renal accumulation while maintaining high tumor affinity and effective uptake.

Indexed as

ClaudinsKidneySingle-Domain AntibodiesStomach NeoplasmsAdenocarcinomaAgedAnimalsCell Line, TumorDisease Models, AnimalGallium RadioisotopesHumansMaleMiceMiddle AgedPilot ProjectsPositron Emission Tomography Computed TomographyClaudinsCLDN18 protein, humanGallium RadioisotopesSingle-Domain AntibodiesCLDN18.2gastrointestinal tumorsrenal uptakesingle-domain antibodytargeted molecular imaging

Identifiers

PMID41819831
PMCPMC13224910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.