Evidence map›Paper›PMID 41819829›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Actionable Feedback on Signal-to-Background Ratios During Drop-in Radioguided Surgery.

Berkay A Cakal, Kateryna Pirkovets, Vera A Ottens, Lotte Zuur, Michiel Sinaasappel, Giorgio Gandaglia, Alberto Briganti, Henk G van der Poel, Pim J van Leeuwen, Fijs W B van Leeuwen

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In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Berkay A CakalInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.
Kateryna PirkovetsInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.
Vera A OttensInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.
Lotte ZuurDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Michiel SinaasappelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Giorgio GandagliaDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; and.
Alberto BrigantiDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; and.
Henk G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Pim J van LeeuwenDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Fijs W B van LeeuwenInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands; f.w.b.van_leeuwen@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioguided surgery (RGS) using prostate-specific membrane antigen (PSMA)-targeted tracers is frequently hampered by relatively low intraoperative signal intensities. This limits intraoperative target discrimination when feedback relies solely on probe counts per second. We evaluated whether real-time signal-to-background ratio (SBR) feedback, integrated into the robotic console via a graphical user interface (GUI), improves surgical perception, decisiveness, and scanning efficiency during drop-in PSMA-radioguided procedures.

Indexed as

FeedbackSignal-To-Noise RatioSurgery, Computer-AssistedAgedAntigens, SurfaceGlutamate Carboxypeptidase IIHumansMaleMiddle AgedProstatic NeoplasmsRetrospective StudiesAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIdrop-in γ-probeprostate cancerPSMAradioguided surgeryrobotic surgery

Identifiers

PMID41819829
PMCPMC13224882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.