ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026
PD-L1 Immuno-PET Reveals Systemic Effects of Localized Oncolytic Virotherapy in a Mouse Model of Head and Neck Cancer.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immune checkpoint inhibitors can trigger antitumor immunity, yet most patients, including those with head and neck cancer, show limited benefit because of insufficient immune activation at the tumor site. Oncolytic virotherapy (OV) may overcome this by priming tumors at the injection site for a stronger response to immune checkpoint inhibitors. However, there are limited data on how OV influences systemic immune responses in uninjected tumors and secondary lymphoid organs (spleen, lymph nodes), largely because of the difficulty of sampling these tissues. We investigated whether immuno-PET can noninvasively track systemic and intratumoral changes in programmed death ligand 1 (PD-L1) expression after intratumoral OV administration in a syngeneic mouse model of oral carcinoma.
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