Evidence map›Paper›PMID 41819589›Full record

ArticleBMJ open2026

Digital Intervention for Psychedelic Preparation (DIPP): protocol for a randomised controlled feasibility trial comparing meditation- and music-based programmes in healthy volunteers.

Rosalind McAlpine, Magdalena Jaglinska, Krisztina Jedlovszky, Joanna Kuc, Ariel Castro, Alexandre Piot, Christopher Timmermann, Jeremy I Skipper, Matthew D Sacchet, Sunjeev K Kamboj

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06815653 (Digital Intervention for Psychedelic Preparation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06815653 phase1recruitingnot on this map

Digital Intervention for Psychedelic Preparation (DIPP): A Randomised Controlled Feasibility Trial Comparing Meditation and Music-Based Programs in Healthy Volunteers.

TypeinterventionalSponsorUniversity College, LondonRan2025 to 2026Enrolled40ConditionsHealthyArmsPsilocybin 25mg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rosalind McAlpineClinical, Educational and Health Psychology, University College London, London, UK rosalind.mcalpine.18@ucl.ac.uk.ORCID http://orcid.org/0000-0002-9435-0655
Magdalena JaglinskaExperimental Psychology, University College London, London, UK.
Krisztina JedlovszkyExperimental Psychology, University College London, London, UK.
Joanna KucExperimental Psychology, University College London, London, UK.
Ariel CastroExperimental Psychology, University College London, London, UK.
Alexandre PiotClinical, Educational and Health Psychology, University College London, London, UK.
Christopher TimmermannExperimental Psychology, University College London, London, UK.
Jeremy I SkipperExperimental Psychology, University College London, London, UK.
Matthew D SacchetHarvard Meditation Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sunjeev K KambojClinical, Educational and Health Psychology, University College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionPsychedelic-assisted therapy shows promise for treating various mental health conditions; however, its reliance on intensive psychological preparation limits its broader application. Digital health interventions have the potential to address this limitation by providing structured, accessible and scalable preparation solutions. This randomised controlled feasibility trial aims to evaluate the feasibility and preliminary efficacy of the Digital Intervention for Psychedelic Preparation (DIPP), a 21-day mobile-accessible programme designed to prepare individuals for psychedelic experiences. METHODS AND ANALYSIS: The study will recruit 40 non-treatment-seeking adults without a clinical diagnosis, randomly assigning them to one of two conditions: (1) DIPP-MEDITATE, which combines daily guided meditation with background music or (2) DIPP-MUSIC, which provides the same background music without guided meditation. Both groups will complete the 21-day digital intervention remotely. Following the intervention, participants will attend an in-person supervised psilocybin session, receiving a standardised 25 mg dose. Primary outcomes focus on feasibility metrics including recruitment efficiency, participant retention and adherence to the intervention protocol. Secondary outcomes assess subjective feasibility, acceptability and preliminary efficacy, specifically evaluating psychedelic preparedness, the quality of the psychedelic experience and changes in wellbeing, with follow-up assessments at 2 weeks, and at 3, 6 and 9 months post-session. Exploratory measures include neuroimaging, physiological, cognitive and psychological assessments, as well as voice note experience sampling through a chatbot (referred to as 'DIPP-bot') to monitor inner speech, thought and emotional states during the intervention and follow-up periods. ETHICS AND DISSEMINATION: Approved by UCL Research Ethics Committee (ID: 19113/003), this study follows the Declaration of Helsinki. Results will be published in peer-reviewed journals and presented at conferences. Confidentiality will be maintained throughout. TRIAL REGISTRATION NUMBER: NCT06815653.

Indexed as

HallucinogensMeditationMusic TherapyPsilocybinAdultDigital HealthFeasibility StudiesFemaleHumansMaleRandomized Controlled Trials as TopicHallucinogensPsilocybinClinical ProtocolsPSYCHIATRYRandomized Controlled TrialTelemedicine

Identifiers

PMID41819589
PMCPMC12983862

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.