Evidence map›Paper›PMID 41819434›Full record

ReviewVascular pharmacology2026

MORF4L1 regulation and its role in chromatin remodeling, DNA damage, cellular senescence, and cardiometabolic disease.

Fatema Yeasmin Tanni, Rachelle Nelson Zoni, Md Atik Faysal, Xinghui Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vascular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fatema Yeasmin TanniDepartment of Biochemistry, University of Nebraska-Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE 68588, USA.
Rachelle Nelson ZoniDepartment of Biochemistry, University of Nebraska-Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE 68588, USA.
Md Atik FaysalSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Xinghui SunDepartment of Biochemistry, University of Nebraska-Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE 68588, USA; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, NE 68588, USA; The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. Electronic address: xsun17@nebraska.edu.

Funding

Role of lncRNA Meg3 in obesity-induced endothelial senescence and insulin resistanceR01HL150536 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI SUN, XINGHUI · 2020 to 2023
$2.0M
Molecular Mechanisms of DiseaseT32GM136593 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Donald F Becker, EDWARD N HARRIS · 2020 to 2026
$1.8M
Regulation of endothelial function and vascular integrity by neddylationR01HL175569 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI Huabo Su, Xinghui Sun · 2025 to 2026
$1.4M
The matrin3-CAR-thrombin axis in hepatic inflammation and fibrosisR01DK145704 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI Xinghui Sun · 2026 to 2026
$529k
NHLBI NIH HHS R01 HL150536NHLBI NIH HHS R01 HL175569NIDDK NIH HHS R01 DK145704NIGMS NIH HHS T32 GM136593
6 · The paper itself

Abstract

Mortality factor 4-like 1 (MORF4L1) is a highly ubiquitinated protein, initially discovered for its role in reversing cellular immortalization. It functions as a component of multi-subunit complexes, including the NuA4 (nucleosome acetyltransferase of H4) histone acetyltransferase, SIN3B histone deacetylase complexes, and histone methyltransferase. It thereby directly influences histone acetylation, methylation, and gene expression. MORF4L1 has emerged as a key player in several biological processes, such as chromatin remodeling, DNA damage response, and cellular senescence. Recent research findings highlight its expanded role in lipid metabolism and metabolic diseases. Genome-wide association studies reveal single-nucleotide polymorphisms near the MORF4L1 locus correlating with lipid traits, type 2 diabetes, and coronary artery disease. This review provides a comprehensive overview of MORF4L1's regulation and its multifaceted roles, implicating its emerging importance in vascular homeostasis and cardiometabolic disease. We propose that MORF4L1's intricate mechanisms demand a deeper understanding. As a regulatory protein at the interface of chromatin biology, cellular senescence, and lipid metabolism, MORF4L1 holds promise as a potential therapeutic target for ameliorating vascular and metabolic dysfunction in cardiometabolic diseases.

Indexed as

Cardiovascular DiseasesCellular SenescenceChromatin Assembly and DisassemblyDNA DamageMetabolic DiseasesAnimalsHumansLipid MetabolismSignal TransductionCardiovascular diseaseCellular senescenceChromatin remodelingDNA damageLipid metabolismMORF4L1

Identifiers

PMID41819434
PMCPMC13049774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.