Evidence map›Paper›PMID 41819433›Full record

ArticleNeuroImage2026

Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker.

Jonghyun Bae, Cassandra M Joynes, Zhaoyuan Gong, Michael R Duggan, Keenan A Walker, Mustapha Bouhrara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jonghyun BaeLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA.
Cassandra M JoynesLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA.
Zhaoyuan GongLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA.
Michael R DugganLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA.
Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA. Electronic address: keenan.walker@nih.gov.
Mustapha BouhraraLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore 21224, MD, USA. Electronic address: bouhraram@mail.nih.gov.

Funding

Understanding immune/inflammatory and vascular mechanisms in brain aging and Alzheimer's diseaseZIAAG000348 · NIA · NATIONAL INSTITUTE ON AGING · PI WALKER, KEENAN · 2021 to 2025
$2.8M
Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA AG000348
6 · The paper itself

Abstract

The myelin sheath is critical for efficient neural signaling and central nervous system function, yet noninvasive methods to quantify myelin content in vivo require robust biological validation. Myelin Water Fraction (MWF) derived from the Bayesian Monte Carlo analysis of multicomponent Driven Equilibrium Single Pulse Observation of T

Indexed as

BrainGray MatterMagnetic Resonance ImagingMyelin SheathNeuroimagingWhite MatterAdultBiomarkersFemaleHumansMaleMultiomicsMyelin Basic ProteinProteomicsSpatial TranscriptomicsWaterBiomarkersMyelin Basic ProteinWaterBMC-mcDESPOTMRI biomarkerMyelin water fractionPlasma proteomicsSpatial transcriptomics

Identifiers

PMID41819433
PMCPMC13084559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.