ReviewIndian pacing and electrophysiology journal
Pulsed field ablation: Biophysical principles and practical considerations in atrial fibrillation treatment.
Review in Indian pacing and electrophysiology journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulsed field ablation (PFA) is an emerging nonthermal ablation modality for the treatment of atrial fibrillation. Unlike conventional thermal energy sources such as radiofrequency and cryoablation, PFA delivers high-voltage pulsed electric fields that induce irreversible electroporation, resulting in selective cardiomyocyte death while largely preserving surrounding extracellular structures. The biological response to pulsed electric fields depends on parameters such as field strength, pulse duration, waveform configuration, and number of pulses. Variations in electroporation thresholds among different cell types contribute to the relative myocardial selectivity observed with PFA. Lesion formation is also influenced by electrode configuration, catheter-tissue contact, and electric field distribution. Early clinical experience and large registries suggest that PFA enables efficient pulmonary vein isolation with a favorable safety profile and reduced risk of collateral injury compared with thermal ablation technologies. This review summarizes the fundamental biophysical mechanisms underlying pulsed electric field ablation and discusses practical considerations for its clinical application in atrial fibrillation ablation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.