Evidence map›Paper›PMID 41819240›Full record

ArticleBrain, behavior, and immunity2026

Lipocalin-2 perpetuates postoperative and post-infectious neuroinflammation and anxiety-like behavior.

Shany E Yang, Jennifer Meng, Colin Johnston, Swapnil Gavade, Will Schwieterman, Holland E Hubert, Michael W Newstead, Benjamin H Singer, Joanna L Spencer-Segal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shany E YangNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Jennifer MengMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, USA.
Colin JohnstonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Swapnil GavadeMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Will SchwietermanMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, USA.
Holland E HubertNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Michael W NewsteadDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Benjamin H SingerDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Joanna L Spencer-SegalMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: sjoanna@med.umich.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Increasing URM Diversity: Targeting Transitions in the Neuroscience Education ContinuumR25NS107159 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERT KEITH DUNCAN, Carol Fuzeti Elias · 2018 to 2026
$2.0M
Neural and Molecular Mechanisms of Emotional Dysfunction after SepsisK08MH116267 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCER-SEGAL, JOANNA LOUISE · 2018 to 2022
$845k
NIDDK NIH HHS P30 DK020572NIMH NIH HHS K08 MH116267NINDS NIH HHS R25 NS107159
6 · The paper itself

Abstract

Lipocalin-2 (LCN2) is a pleiotropic cytokine with well-established roles in immune defense, iron metabolism, and inflammation that has been used as a biomarker for kidney injury, cancer, and infection. Recent work has also suggested a role for LCN2 in brain function and behavior, suggesting that LCN2 excess could be a driver of neuropsychiatric complications of infectious and inflammatory conditions. Here, we show that LCN2 levels remain elevated in both the brain and circulation for weeks after an acute infection or simple laparotomy in male and female mice. We used an inducible knockout mouse model to decrease lcn2 expression after recovery from surgery and infection and found that higher brain lcn2 RNA levels predicted persistent neuroinflammation and anxiety-like behavior in survivors. Exogenous LCN2 administration increased in vivo activity of hippocampal CA1 pyramidal cells and increased anxiety-like behavior in male mice. Together, these findings reveal a novel role for LCN2 as a neuroinflammatory mediator of long-term neuropsychiatric dysfunction in infection survivors.

Indexed as

AnxietyLipocalin-2Neuroinflammatory DiseasesAnimalsBrainDisease Models, AnimalFemaleHippocampusInflammationMaleMiceMice, Inbred C57BLMice, KnockoutLcn2 protein, mouseLipocalin-2Anxiety-like behaviorCecal ligation and punctureInfectionLaparotomyLipocalin-2NeuroinflammationPost-sepsis syndromeSepsis

Identifiers

PMID41819240
PMCPMC13455570

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.