Evidence map›Paper›PMID 41819125›Full record

ArticleJournal of applied toxicology : JAT2026

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver.

Thainá Iasbik-Lima, Luiz Otávio Guimarães-Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado-Neves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thainá Iasbik-LimaDepartamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Luiz Otávio Guimarães-ErvilhaDepartamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-6355-2492
Isabela Pereira da Silva BentoDepartamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Renê Chagas da SilvaDepartamento de Física, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Mariana Machado-NevesDepartamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-7416-3529

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 313524/2021-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.584671/2020-00Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00361-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais BPD-00843-22Fundação de Amparo à Pesquisa do Estado de Minas Gerais PPM-00621-18
6 · The paper itself

Abstract

Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore, this study aimed to evaluate the effects of individual and combined ingestion of arsenic and nickel on the rat liver. Adult males (n = 10/group) received saline (control), 1 mg L

Indexed as

LiverNickelNitrosative StressAnimalsMaleOxidative StressRatsRats, WistarToxicity Tests, SubchronicNickelhepatotoxicityhistomorphometryinflammationmetal mixturenitric oxide

Identifiers

PMID41819125
PMCPMC13628411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.