ArticleJournal of diabetes2026
Associations of Sarcopenia and Sarcopenic Obesity Using Different Obesity Definitions With Memory Decline.
Article in Journal of diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo explore the associations of sarcopenia and sarcopenic obesity (SO) with memory. MATERIALS AND
methodsData from the Guangzhou Biobank Cohort Study (GBCS) were used to conduct both cross-sectional (n = 6390) and longitudinal (n = 3979) analyses. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019, while obesity was defined by 20 obesity indicators. Memory was assessed by the Delayed Word Recall Test (DWRT). Linear regression was used to analyze these associations. Two-sample Mendelian randomization (2SMR) was used to investigate potential causal associations of sarcopenia-related traits with memory.
resultsCompared to participants without sarcopenia, those with sarcopenia had lower baseline and follow-up DWRT score, and greater decrease in mean annual change (MAC) and MAC rate of DWRT score, with adjusted βs (95% CIs) being -0.24 (-0.33 to -0.14), -0.10 (-0.20 to -0.004), -0.03 (-0.06 to -0.001) and -0.79 (-1.57 to -0.01), respectively. Among all the SO definitions, the associations of SO defined by waist-to-hip-to-height ratio (WHHR) appeared to be the strongest (-0.36 [-0.50 to -0.22], -0.31 [-0.45 to -0.17], -0.09 [-0.14 to -0.05] and -2.70 [-3.81 to -1.59]), and stronger than those with sarcopenia only or obesity only. In 2SMR, walking pace (one of the sarcopenia indicators) was positively associated with working memory (1.61 [0.59, 2.62]).
conclusionsSarcopenia and SO were associated with faster memory decline. Using the central obesity indicator WHHR to define SO may better predict late-life memory.
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