Evidence map›Paper›PMID 41818887›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Long-term efficacy of the treat-to-close strategy for patients with atrial septal defect-pulmonary artery hypertension and characteristics of indicated populations.

Jianing Fan, Yuliang Long, Jin Qi, Dawei Lin, Feng Zhang, Zhi Zhan, Dandan Chen, Wenzhi Pan, Lihua Guan, Daxin Zhou and 1 more

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In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianing FanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Yuliang LongDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Jin QiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Dawei LinDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Feng ZhangDepartment of Cardiology, Jinshan Hospital, Fudan University, Shanghai, China.
Zhi ZhanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Dandan ChenDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Wenzhi PanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Lihua GuanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China. Electronic address: guan.lihua@zs-hospital.sh.cn.
Daxin ZhouDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China. Electronic address: Daxin_Zhou@163.com.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, National Clinical Research Center for Interventional Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective"Treat-to-close" strategy in the treatment of patients with Atrial Septal Defects (ASD) combined with severe Pulmonary Hypertension (PAH). This study explored the long-term survival of patients undergoing the "treat-to-close" strategy and the characteristics of the applicable population.

methodsA total of 141 ASD-PAH patients were collected. Patients were classified as "Occlusion Group" (OG) and "Conservative Treatment Group" (CTG) depending on the suitability of ASD occlusion after drug treatment. The baseline characteristics and long-term follow-up outcomes of the two groups were recorded.

resultsPatients in the OG underwent 5 (3.8) months of Pulmonary Artery-targeted Drug Therapy (PADT) before ASD occlusion. OG patients had better long-term survival (p = 0.043). Pulmonary Vascular Resistance (PVR): Area Under the Curve (AUC) 0.813 (0.726‒0.899, p < 0.001), Pulmonary Arterial Oxygen Saturation (PASO2): AUC = 0.794 (95% CI: 0.682‒0.904 p < 0.001), Pulmonary Artery Systolic Pressure (PASP): AUC = 0.808 (95% Confidence Interval [95% CI]: 0.733‒0.883 p < 0.001) and PASO2 combined with PASP: 0.918 (95% CI: 0.854‒0.979 p < 0.001) contribute to the screening of drug-sensitive populations.

conclusionsThe treat-to-close strategy significantly improves long-term patient survival. Initial intraoperative indications can help screen the beneficiary population. Larger-scale prospective studies are needed to validate the present findings.

Indexed as

Atrial septal defectNon-correctableNon-repairablePulmonary arterial hypertensionTreat-to-Close

Identifiers

PMID41818887
PMCPMC12994034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.