ArticleCancer research communications2026
Predominant Merkel Cell Polyomavirus DNA Detection in Essential Thrombocythemia within Myeloproliferative Neoplasms.
Article in Cancer research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute thrombocythemic myeloproliferative disease in mice has been reported upon introduction of middle T gene expression of mouse polyomavirus. Merkel cell polyomavirus (MCPyV) is an oncogenic human polyomavirus that accounts for approximately 80% of all Merkel cell carcinomas. In this study, we assessed the presence of MCPyV DNA in fresh bone marrow (BM) aspirates from patients with myeloproliferative neoplasms (MPN) using MCPyV-specific DNA polymerase chain reaction. MCPyV DNA prevalence was significantly higher in 78 BM samples from patients with MPNs (17.9%, 14/78) than in 66 BM controls undergoing femoral head replacement surgery (3%, 2/66; Fisher exact test, P = 0.0063; OR = 7.95% confidence interval = 1.53-32.06). Notably, positivity was predominant in essential thrombocythemia (ET; 11/14). MCPyV mRNA was detected in MCPyV DNA-positive samples, indicating low-level viral transcription. Interestingly, MCPyV positivity was significantly correlated with female sex but not with age or specific MPN genetic mutations, except for myeloproliferative leukemia virus oncogene mutations. These findings suggest a potential association between MCPyV and MPNs, particularly ET, and support further investigation into the role of human polyomavirus in megakaryocytic lineage biology. SIGNIFICANCE: MCPyV DNA was detected in BM samples from patients with MPNs, especially those with ET. This observation suggests possible involvement of MCPyV in megakaryocytic lineage biology, providing new insights into MPN pathogenesis and promoting further investigation into the role of human polyomaviruses in hematologic disorders.
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