ArticleSkin pharmacology and physiology2026
Cysteinamide Enhances Fibroblast Survival and Wound Healing by Preventing Serum Deterioration in High-Glucose Conditions.
Article in Skin pharmacology and physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
<p>Introduction: In patients with diabetes, persistent hyperglycemia causes chemical changes in serum components, increasing the incidence of various complications such as skin wounds. To better understand glucose-associated chemical stress on serum components, this study explores small-molecule nutrients to protect human dermal fibroblasts (HDFs) from glucose-rich, chemically deteriorated culture conditions.
methodsVarious cell culture media with different concentrations of glucose and various test compounds were subjected to heat treatment as a chemically accelerated model of serum deterioration. The heat-treated and non-heat-treated media were compared to each other in terms of the content of glycation products and their effects on cell viability and wound healing in vitro.
resultsThere was no difference in the content of glycation products or their effects on cell viability between the non-heat-treated low-glucose (LG, 5.5 m<sc>m</sc>) and high-glucose (HG, 50 m<sc>m</sc>) media that were not heat treated. However, the heat-treated HG media had a higher content of glycation products and decreased cell viability compared to the heat-treated LG media. Of the 20 free amino acids, 20 amidated amino acids and various antioxidants derived from cysteine (Cys) or ascorbic acid (AA) added to the media, followed by heat treatment, only cysteinamide (C-NH
conclusionThese findings provide proof-of-concept evidence that C-NH
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.