ArticleNeuroimmunomodulation2026
Prebiotic Diet Enhances Suppression of Tumor Necrosis Factor-Alpha Production in Response to Lipopolysaccharide after Exhaustive Exercise.
Article in Neuroimmunomodulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough it is well known that severe exercise induces temporary immunosuppression, it remains unclear the effect of gut microbiota on this phenomenon.
methodsIn this study, to investigate the effect of gut microbiota on the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production immediately after the exhaustive exercise, C3H/HeN male mice were (1) treated with or without antibiotic (AB), (2) transplanted cecal content from a 5% partially hydrolyzed guar-gum (PHGG) diet, which is classified as low viscous in dietary fiber, fed mice, and (3) intake PHGG diet for 6 weeks. The mice were stimulated by LPS administration immediately after loaded forced exhaustive exercise.
resultsAfter the exhaustive exercise, plasma TNF-α concentration in AB mice prior to response from LPS was significantly higher than that in control mice (p < 0.01). On the other hand, differences in transplanted cecal contents did not affect TNF-α production by exercise prior to LPS administration. Direct intake of PHGG, however, attenuated the increase in plasma TNF-α concentration in response to LPS, compared with both non-fiber and control diet groups (p < 0.01).
conclusionThese results suggest that LPS-induced TNF-α production immediately after intense exercise is regulated depending on both the composition of the gut microbiota and the material being fermented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.