Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
26 authors.
Alejandro Collado-SoleTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-7117-6896
Nozha BorjiniInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0003-3729-2521
Jing ZhaiService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Francisco Ruiz-PinoInstituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia, Córdoba, Spain.ORCID 0000-0002-9217-8230
Gonzalo Soria-AlcaideTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-5141-2177
Cintia FolgueiraCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0003-3803-9149
Celia García-VilelaDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.ORCID 0000-0002-6234-0487
Beatriz Romero-de la RosaInstituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia, Córdoba, Spain.ORCID 0009-0003-0432-247X
Victor LopezTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Yassine ZouaghiService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
An JacobsDepartment of Medicine, Endocrinology, Diabetology, and Metabolism Unit, CHUV, Lausanne, Switzerland.ORCID 0000-0003-2556-4454
Bella Mora-RomeroInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Alexandra BarrancoTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-9836-9812
Guillermo YoldiOncobell, Bellvitge Biomedical Research Institute, IDIBELL, Barcelona, Spain.ORCID 0000-0001-6144-4543
Karine RizzotiLaboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, London, UK.ORCID 0000-0003-0711-5452
Guadalupe SabioTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-2822-0625
Gema Perez-ChaconTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-2081-0882
Patricia G SantamariaTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Jose Antonio EstebanDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.ORCID 0000-0002-3759-3300
Nathalie JourniacLille University, Inserm, CHU Lille, Lille Neuroscience and Cognition, UMR-S 1172, Labex DistAlz, Lille, France.ORCID 0000-0001-6328-0802
Vincent PrevotLille University, Inserm, CHU Lille, Lille Neuroscience and Cognition, UMR-S 1172, Labex DistAlz, Lille, France.ORCID 0000-0001-7185-3615
Alberto PascualInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0001-5459-6207
Rafael Fernández-ChacónInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0002-9845-9885
Manuel Tena-SempereInstituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia, Córdoba, Spain.ORCID 0000-0002-4741-5567
Nelly PitteloudService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0003-0971-3237
Eva Gonzalez-SuarezTumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-0858-8171
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We identified a role of hypothalamic microglia in controlling the HPG axis through receptor activator of nuclear factor κB (Rank) signaling. Whole-body and microglia Rank (mouse) depletion led to hypogonadotropic hypogonadism (HH) resulting from an alteration in gonadotropin-releasing hormone (GnRH) neuron function. In addition, we identified rare gene variants of
Indexed as
Gonadotropin-Releasing HormoneHypogonadismHypothalamic-Pituitary-Gonadal AxisMicrogliaNeuronsReceptor Activator of Nuclear Factor-kappa BAnimalsFemaleFertilityGonadsHumansHypothalamusKisspeptinsMaleMedian EminenceMiceGonadotropin-Releasing HormoneKisspeptinsReceptor Activator of Nuclear Factor-kappa BTnfrsf11a protein, mouse
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis. · full record | OpenQuestion