Evidence map›Paper›PMID 41817925›Full record

ArticleActa parasitologica2026

Efficacy of Imidazolium Salt in Disinfecting Soft Contact Lenses Contaminated with Acanthamoeba spp. Trophozoites.

Natasha Cristine Gonçalves, Igor Luiz Gonçalves Pereira, Henri Stephan Schrekker, Diane Ruschel Marinho, Marilise Brittes Rott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natasha Cristine GonçalvesProtozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-002, Brazil.
Igor Luiz Gonçalves PereiraLaboratory of Technological Processes and Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, 9500 Bento Gonçalves Avenue, Porto Alegre, RS, 91501-970, Brazil.
Henri Stephan SchrekkerLaboratory of Technological Processes and Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, 9500 Bento Gonçalves Avenue, Porto Alegre, RS, 91501-970, Brazil.
Diane Ruschel MarinhoCornea Department, Ophthalmology Service, Porto Alegre Clinical Hospital, 2350 Ramiro Barcelos Street, Porto Alegre, RS, 90035-903, Brazil.
Marilise Brittes RottProtozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-002, Brazil. marilise.rott@ufrgs.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAcanthamoeba spp. can infect the cornea due poor lens hygiene allows colonization, and current cleaning solutions are ineffective due to resistant cyst formation. This study aimed to establish, for the first time, a standardized protocol for Acanthamoeba trophozoite adhesion to silicone hydrogel soft contact lenses and to quantify the impact of lens–drug interactions on antiparasitic efficacy. Additionally, the study evaluated the efficacy of 1-hexadecyl-3-methylimidazolium chloride (C16MImCl) against Acanthamoeba trophozoites in the presence of soft contact lenses, in comparison with a commercial contact lens solution and chlorhexidine.

methodsA protocol for trophozoites adhesion to silicone hydrogel contact lenses was developed, and the antiparasitic activity of C16MImCl was compared to that of a commercial solution and chlorhexidine.

resultsC16MImCl effectively eliminated all trophozoites in the presence of contact lenses and prevented encystment at concentrations ten times the minimum inhibitory concentration, despite partial absorption by contact lenses. Notably, it showed greater corneal cell viability than chlorhexidine, highlighting its potential as a safer alternative.

conclusionThese results underscore its strong anti-amoebic activity, outperforming the commercial solution tested. While further cytotoxicity studies and tests simulating ocular conditions are warranted, C16MImCl emerges as a promising candidate for a future contact lens cleaning and decontamination solution.

Indexed as

AcanthamoebaContact Lenses, HydrophilicDisinfectantsDisinfectionImidazolesTrophozoitesAcanthamoeba KeratitisChlorhexidineContact Lens SolutionsCorneaHumansChlorhexidineContact Lens SolutionsDisinfectantsImidazolesAcanthamoebaContact lensesCorneaImidazolium saltKeratitis

Identifiers

PMID41817925
PMCPMC12982248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.