ReviewDrugs & aging2026
Harms of Continued Antihypertensives: An Overview of Reviews.
Review in Drugs & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAntihypertensives are effective drugs for treatment of hypertension, which is one of the most important risk factors for cardiovascular morbidity. Intensive hypertension treatment significantly reduces cardiovascular risk among older people. Based on these findings, guidelines recommend stricter blood pressure management nowadays. Reasoning on benefit and harms of antihypertensive treatment can be challenging in daily practice because little evidence is available on specific harm outcomes.
objectiveWith this overview of reviews, we aim to summarize evidence from systematic reviews on harms associated with continued antihypertensive treatment.
methodsWe searched Ovid MEDLINE, Ovid Embase and the Cochrane Library for systematic reviews with or without meta-analysis. Included were all systematic reviews of randomized and non-randomized controlled trials on harms of antihypertensive drugs in English. Any other type of article was excluded. Change in focused on the older population.
resultsThe search resulted in 6353 items. A total of 105 articles were eligible for full-text screening, and 47 articles fulfilled eligible criteria and were included. Most common side effects included respiratory symptoms like dry cough (particularly under angiotensin-converting enzyme inhibitors), hypotensive symptoms, renal failure and electrolyte misbalances.
conclusionAntihypertensives have a broad spectrum of side effects, but they are effective drugs against hypertension and reduce cardiovascular disease burden.
Indexed as
Identifiers
41817868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.