Evidence map›Paper›PMID 41817863›Full record

ArticleBiomedical microdevices2026

Neuroendoscopy-compatible neurostimulation catheter for minimally-invasive and multifunctional hypothalamic deep brain stimulation.

Jae Young Park, Juan C Mesa, Jongcheon Lim, Deniz Eksioglu, Sergio Ruiz Vega, Albert Lee, Hyowon Lee

Abstract read
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In one paragraph

Article in Biomedical microdevices, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jae Young ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Juan C MesaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Jongcheon LimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Deniz EksiogluWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Sergio Ruiz VegaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Albert LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. hwlee@purdue.edu.

Funding

National Science Foundation ECCS-1944480
6 · The paper itself

Abstract

As hypothalamic deep brain stimulation (DBS) has been clinically proven effective for treating various neurological conditions, there is a growing need for strategies that minimize invasiveness while maximizing therapeutic efficacy. We propose a highly translational multifunctional neurostimulation catheter compatible with endoscopic access to the third ventricule for targeted ventromedial hypothalamic deep brain stimulation. This approach offers several key advantages: (1) a multifunctional catheter for both electrical and pharmaceutical intervention, (2) a minimally-invasive implantation procedure, and (3) enhanced electrode contacts with the third ventricle wall to access the underlying hypothalamic nuclei. The system comprises a flexible catheter with integrated thin-film microelectrodes, a customized cylindrical connector, extension wires, and a customized neurostimulator. The design features its high compatibility with clinically available neurosurgical tools, including guide wires and burr hole valves. We evaluated electrochemical performance under various bending conditions and assessed the safety and long-term device reliability. In addition, we demonstrated successful implantation into a Polydimethylsiloxane (PDMS) mold shaped to sit in the third ventricle, simulated the electric potential distribution using finite element analysis, and validated a clinically compatible drug delivery procedure. This novel implantation strategy holds promise for reducing procedural risks associated with hypothalamic deep brain stimulation.

Indexed as

CathetersDeep Brain StimulationHypothalamusNeuroendoscopyAnimalsEquipment DesignMicroelectrodesBiomedical microdeviceDeep brain stimulationImplantable medical deviceNeural interfaceNeuroengineeringNeurosurgery

Identifiers

PMID41817863
PMCPMC12982212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.