Evidence map›Paper›PMID 41817597›Full record

ArticleJCI insight2026

Human antibody repertoire among kidney donors with and without HIV.

Xianming Zhu, William R Morgenlander, Diane M Brown, Yolanda Eby, Megan Morsheimer, Jonah Odim, Serena M Bagnasco, Meenakshi M Rana, Sander S Florman, Rachel J Friedman-Moraco and 28 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03500315 (HOPE in Action Prospective Multicenter, Clinical Trial of Deceased HIVD+ Kidney Transplants for HIV+ Recipients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03500315 nacompletednot on this map

HOPE in Action Prospective Multicenter, Clinical Trial of Deceased HIVD+ Kidney Transplants for HIV+ Recipients

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2024Enrolled209ConditionsHivArmsHIV D+/R+
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Xianming ZhuDepartment of Epidemiology, Bloomberg School of Public Health.
William R MorgenlanderDepartment of Pathology, School of Medicine, and.
Diane M BrownDepartment of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Yolanda EbyDepartment of Pathology, School of Medicine, and.
Megan MorsheimerDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Jonah OdimDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Serena M BagnascoDepartment of Pathology, School of Medicine, and.
Meenakshi M RanaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sander S FlormanRecanati-Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York, USA.
Rachel J Friedman-MoracoDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Peter G StockDepartment of Surgery, University of California, San Francisco, San Francisco, California, USA.
Alexander J GilbertDepartment of Medicine, Georgetown University, Washington, DC, USA.
Shikha MehtaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Valentina StosorDivisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sapna A MehtaNew York University Langone Transplant Institute, New York, New York, USA.
Marcus R PereiraDepartment of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Catherine B SmallDepartment of Medicine, Weill Cornell Medicine, New York, New York, USA.
Michele I MorrisDivision of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jonathan HandDepartment of Medicine, Ochsner Health, New Orleans, Louisiana, USA.
Saima AslamDivision of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA.
Ghady HaidarDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Maricar MalinisSection of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA.
Carlos Aq SantosDivision of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA.
Joanna SchaenmanDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
David WojciechowskiDepartment of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Karthik RangannaDepartment of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Emily BlumbergDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nahel EliasDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Josa A Castillo-LugoDepartment of Medicine, Methodist Health System Clinical Research Institute, Dallas, Texas, USA.
Emmanouil GiorgakisDepartment of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Senu ApewokinDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
M Kate GrabowskiDepartment of Epidemiology, Bloomberg School of Public Health.
Dorry L SegevDepartment of Surgery and.
Andrew D ReddDepartment of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Christine M DurandDepartment of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
H Benjamin LarmanDepartment of Pathology, School of Medicine, and.
Aaron Ar TobianDepartment of Pathology, School of Medicine, and.
HOPE in Action investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDTransplanting kidneys from donors with HIV to recipients with HIV has become standard clinical practice. However, donors with HIV may have higher prevalence of viral and bacterial infections and autoimmunity that could increase allograft rejection in recipients.METHODSWe included deceased kidney donors (60 with HIV and 41 without HIV) who participated in a multicenter prospective study of HIV kidney transplantation between April 2018 and September 2021. Using phage immunoprecipitation sequencing, we compared the human antibody repertoire (allergens, autoantibodies, viruses, and bacterial toxins) between donors with and without HIV and evaluated their association with recipient allograft rejection. Moderated t tests were used to assess reactivity and a multivariate logistic regression model adjusted for donor sex and kidney donor profile index assessed the association between donor adenovirus reactivity and recipient allograft rejection.RESULTSCompared with donors without HIV, donors with HIV had lower BMI and were more likely to be African American. The median number of positive autoantibodies was marginally higher among donors with HIV (499 [IQR, 357, 579]) compared with that of donors without HIV (395 [IQR, 256, 538], P = 0.058). Donors with HIV additionally had significantly higher antibody reactivity to Epstein-Barr virus and cytomegalovirus (q < 0.05). Among all donors with and without HIV, antibodies against adenovirus were significantly associated with increased rejection among recipients, including after adjusting for false discovery (q < 0.05) and also adjusting for demographic factors using multivariable logistic regression (odds ratio = 4.97; 95% CI = 1.89-13.61).CONCLUSIONThe presence of antibodies against adenovirus infection in kidney donors with HIV may be associated with allograft rejection.TRIAL REGISTRATIONClinicalTrials.gov NCT03500315.FUNDINGUS NIH.

Indexed as

Graft RejectionHIV InfectionsKidney TransplantationTissue DonorsAdultAutoantibodiesFemaleHumansMaleMiddle AgedProspective StudiesAutoantibodiesAIDS/HIVInfectious diseaseOrgan transplantationPublic Health

Identifiers

PMID41817597
PMCPMC13135408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.