ArticleJACC. Case reports2026
Immediate Reversal of Hypoxemia With PFO Closure in Carcinoid Heart Disease and Platypnea-Orthodeoxia Syndrome.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracardiac shunting via a patent foramen ovale (PFO) is an under-recognized cause of refractory hypoxemia. CASE SUMMARY: A 48-year-old woman with metastatic gastric neuroendocrine tumor involving the tricuspid valve presented with recurrent shortness of breath and severe hypoxemia refractory to supplemental oxygen. Computed tomography angiography ruled out pulmonary embolism. Transthoracic echocardiography with a bubble study demonstrated an interatrial communication suggesting a PFO. Right heart catheterization showed bidirectional shunting. Intracardiac echocardiography confirmed the presence of a large PFO. The patient underwent percutaneous PFO closure with an Amplatzer PFO Occluder, resulting in marked improvement in oxygenation and resolution of respiratory failure. DISCUSSION: This case underscores the importance of considering intracardiac shunts in instances of unexplained refractory hypoxemia and demonstrates the efficacy of percutaneous PFO closure in treating this phenomenon. TAKE-HOME MESSAGES: Consider a PFO in persistent hypoxemia despite a negative pulmonary work-up. Timely percutaneous closure may lead to rapid, sustained improvement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.