Evidence map›Paper›PMID 41817308›Full record

ArticleEuropean journal of immunology2026

Non-cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC-E Restricted CD8 T Cell Population.

Xiaokun Yang, Melissa A Colden, Rachel Coombs, Kathya Arana, Dan Tran, Michael Manoharan Valerio, Ellen A Robey, Laurent Coscoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaokun YangDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.ORCID 0009-0005-7277-5301
Melissa A ColdenDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Rachel CoombsDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Kathya AranaDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Dan TranDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Michael Manoharan ValerioDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Ellen A RobeyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Laurent CoscoyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

Funding

Signals That Control Thymocyte MigrationR01AI064227 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ELLEN A ROBEY · 2006 to 2026
$7.4M
Training Research Educators in Minnesota (TREM) whilst increasing diversityK12GM119955 · NIGMS · UNIVERSITY OF MINNESOTA · PI David Irwin Greenstein, Julia Willett · 2017 to 2026
$6.5M
Presentation of Qa-1 restricted peptides during homeostasis and viral infectionR01AI149341 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI COSCOY, LAURENT, ROBEY, ELLEN A · 2020 to 2024
$2.9M
National Institute of Allergy and Infectious Diseases RO1AI149341NIAID NIH HHS R01 AI064227NIAID NIH HHS R01 AI149341NIGMS NIH HHS K12 GM119955
6 · The paper itself

Abstract

MHC-E-restricted CD8 T cells are emerging as an attractive therapeutic mechanism due to their strong protective capacity and ability to respond to cells with defects in antigen processing; however, their thymic development remains poorly understood. Here, we explore the MHC ligand requirement for thymic development of T cells reactive to a self-peptide (FL9) presented by mouse MHC-E (Qa1

Indexed as

CD8 AntigensCD8-Positive T-LymphocytesHistocompatibility Antigens Class IAminopeptidasesAnimalsAntigen PresentationClonal Selection, Antigen-MediatedHLA-E AntigensMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellThymocytesThymus GlandAminopeptidasesCD8 AntigensHistocompatibility Antigens Class IHLA-E AntigensQ surface antigensReceptors, Antigen, T-CellCD8MHC‐EQa1bQFL T cellT cell development

Identifiers

PMID41817308
PMCPMC12981212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.