Evidence map›Paper›PMID 41817307›Full record

ArticleEuropean journal of immunology2026

Transcriptome-Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass-Specific Phenotypes.

Jana Koers, Arie J Hoogendijk, Simon Tol, Floris P J Van Alphen, Ninotska I L Derksen, Maartje van den Biggelaar, Theo Rispens

Abstract read
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In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jana KoersSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Arie J HoogendijkSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Simon TolSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Floris P J Van AlphenSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Ninotska I L DerksenSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Maartje van den BiggelaarSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Theo RispensSanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9600-1312

Funding

Landsteiner Foundation for Blood Transfusion 1626
6 · The paper itself

Abstract

Antibodies produced by B cells aid in the recognition and clearance of pathogens and are the cornerstone of vaccination strategies. Humans produce nine different antibody isotypes, and their effector functions differ according to the type of antigen and route of exposure. Phenotypic variation between isotype-switched B cell subsets is expected but not studied in detail. To obtain a molecular definition of isotype-defined cell identity, we performed proteomics and transcriptomics on isotype-defined populations of human naive and memory B cells (MBCs): CD27

Indexed as

B-Lymphocyte SubsetsImmunoglobulin IsotypesMemory B CellsProteomeTranscriptomeCell DifferentiationGene Expression ProfilingHumansImmunoglobulin Class SwitchingImmunoglobulin GImmunologic MemoryPhenotypeProteomicsImmunoglobulin GImmunoglobulin IsotypesProteomeB cellsIgG4Isotypesproteomicstranscriptomics

Identifiers

PMID41817307
PMCPMC12981214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.