Evidence map›Paper›PMID 41817257›Full record

ArticleJACC. Case reports2026

Adjuvant Cilostazol Therapy to Help Restore Atrioventricular Conduction in Lyme Carditis.

Bipin Aryal, Pratima Mandal, Markus F Meyer

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bipin AryalDivision of Cardiovascular Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: bipinaryal038@gmail.com.
Pratima MandalDivision of Cardiovascular Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Markus F MeyerDivision of Cardiovascular Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: MarkusMeyerMD@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLyme carditis commonly presents with varying degrees of atrioventricular (AV) conduction abnormalities. CASE SUMMARY: A 41-year-old man presented with worsening fatigue, dizziness, and shortness of breath and a second-degree AV block. Laboratory testing confirmed an infection with Borrelia burgdorferi. The patient received intravenous ceftriaxone but remained in a 2:1 AV block. Addition of cilostazol, an oral phosphodiesterase-3 inhibitor that enhances nodal conduction, was associated with prompt restoration of AV conduction. DISCUSSION: Adjunctive cilostazol may help restore conduction in select patients with higher-grade AV block. The effectiveness of this approach will need to be confirmed in prospective randomized studies. The case and rationale for this approach are discussed. TAKE-HOME MESSAGES: Lyme carditis should be suspected in younger patients with new AV block because timely recognition ensures that complete recovery after antibiotic therapy is initiated. By enhancing nodal conduction, cilostazol may reduce the need for temporary pacing and shorten hospitalization.

Indexed as

blood testsbradycardiaelectrocardiogramsecondary preventiontreatment

Identifiers

PMID41817257
PMCPMC13002493

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.