ArticleJACC. Case reports2026
Utilizing Electronic Health Record-Based Alerts to Increase Prescription of Lipid-Lowering Therapies in Patients Admitted With Acute Coronary Syndromes.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients hospitalized with acute coronary syndromes (ACS) are at high risk of recurrent events, yet lipid-lowering therapy is often underutilized despite strong guideline recommendations. PROJECT RATIONALE: To address treatment gaps, we implemented a real-time electronic health record (EHR) alert prompting optimization of lipid-lowering therapy for patients hospitalized with ACS. PROJECT SUMMARY: An interruptive EHR alert, triggered on ACS admission, encouraged statin intensification or ezetimibe initiation. Among 612 patients from 2021 to 2025, 20.6% of alerts were accepted. Therapy was intensified in 61.3% of patients overall. In addition, 6-month preintervention data suggested significant increases in both ezetimibe prescribing (3.3% increasing to 13.7%, P = 0.002) and statin prescribing or intensification (44.9% increasing to 55.1%, P = 0.016) following the implementation of the EHR alert. TAKE-HOME MESSAGE: Real-time EHR alerts can prompt both direct and indirect lipid therapy intensification in ACS care, improving adherence to guideline-directed lipid-lowering therapy and promoting more effective secondary prevention.
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