Evidence map›Paper›PMID 41817253›Full record

ArticleJACC. Case reports2026

Aortic Root Thrombosis With Multivessel Coronary Embolism Following Left Ventricular Assist Device Implantation.

Radhay Parikh, Chloe Kharsa, Rody G Bou Chaaya, Gal Sella, Mangesh Kritya, Karl Abou Zeid, Mahwash Kassi, Neal Kleiman, Alpesh R Shah

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Radhay ParikhBaroda Medical College, Vadodara, Gujarat, India.
Chloe KharsaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Rody G Bou ChaayaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Gal SellaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Mangesh KrityaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Karl Abou ZeidDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Mahwash KassiDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Neal KleimanDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Alpesh R ShahDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA. Electronic address: ARShah@houstonmethodist.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic root thrombosis is uncommon but potentially catastrophic in patients supported with continuous-flow left ventricular assist devices (LVADs). CASE SUMMARY: We describe a 28-year-old woman presenting with syncope 1 month after HeartMate 3 LVAD implantation. Electrocardiography demonstrated a myocardial infarction. Echocardiography revealed severe biventricular dysfunction, persistent aortic valve closure, and normal LVAD inflow velocities. The international normalized ratio was 1.4. Coronary angiography identified a mobile aortic root thrombus with multivessel coronary embolization. Given prohibitive embolic risk, intensive medical therapy was pursued, leading to clinical stabilization. DISCUSSION: Early recognition and multidisciplinary management are critical when invasive strategies carry high risk. TAKE-HOME MESSAGES: Aortic root thrombosis is a rare but life-threatening complication in patients supported with continuous-flow LVADs. Acute ST-segment elevation myocardial infarction in patients with LVAD should prompt urgent evaluation for coronary embolism rather than atherosclerotic disease, especially in young patients without traditional risk factors. Management of aortic root thrombus with multivessel coronary embolization requires individualized, multidisciplinary decision-making.

Indexed as

anticoagulationaortic root thrombosiscoronary embolismHeartMate 3left ventricular assist devicemyocardial infarction

Identifiers

PMID41817253
PMCPMC13002487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.