ArticleJACC. Case reports2026
Non-ST-Segment Elevation Myocardial Infarction as the Initial Presentation of Chronic Lymphocytic Leukemia.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundAcute coronary syndrome is an uncommon initial manifestation of chronic lymphocytic leukemia (CLL). CASE SUMMARY: A 55-year-old man presenting with non-ST-segment elevation myocardial infarction. Coronary angiography revealed thrombotic total mid-left anterior descending artery occlusion, and intravascular ultrasound confirmed a fibro-fatty plaque, successfully treated with percutaneous coronary intervention. Laboratory testing revealed marked lymphocytosis, and flow cytometry confirmed Rai stage I CLL, managed conservatively under hematologic supervision. DISCUSSION: Myocardial infarction as the first manifestation of CLL is exceedingly rare and may occur due to leukostasis, coronary infiltration, or a paraneoplastic prothrombotic mechanism. The multimodality imaging assists in identifying mechanisms. TAKE-HOME MESSAGES: Persistent lymphocytosis during acute coronary syndrome warrants hematologic evaluation. CLL may rarely present with myocardial infarction. Recognition of this presentation is crucial for timely multidisciplinary management.
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